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Volume 30 Issue 9
Sep.  2014
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WANG Yu-qin, YU Xiao-ting, WU Xiao-lan.et al, . Effects of polygonatum sibiricum polysaccharides on free radical metabolism in brain tissue of mice at exhaustion and recovery[J]. Chinese Journal of Public Health, 2014, 30(9): 1165-1167. doi: 10.11847/zgggws2014-30-09-18
Citation: WANG Yu-qin, YU Xiao-ting, WU Xiao-lan.et al, . Effects of polygonatum sibiricum polysaccharides on free radical metabolism in brain tissue of mice at exhaustion and recovery[J]. Chinese Journal of Public Health, 2014, 30(9): 1165-1167. doi: 10.11847/zgggws2014-30-09-18

Effects of polygonatum sibiricum polysaccharides on free radical metabolism in brain tissue of mice at exhaustion and recovery

doi: 10.11847/zgggws2014-30-09-18
  • Received Date: 2013-12-25
  • Publish Date: 2014-09-10
  • Objective To observe the effects of polygonatum sibiricum polysaccharides (PSP) on free radical metabolism in brain tissue of the mice at the time of exhaustion and recovery.Methods Seventy-two Kunming mice were randomly divided into three groups:normal group(N),high (H) and low(L) dose PSP group.The mice in the H and L dose groups were administered with PSP by gavage once a day for 4 weeks and those in the N group were treated with a same amount of normal saline.By the end of the treatment,the mice of the 3 groups were sacrificed at the time of rest state,the immediate end of exhaustive exercise and 24 hours after the end of exhaustive exercise,respectively.The content of malonaldehyde(MDA),the activity of superoxide dismutase (SOD) and glutathione peroxidase(GSH-Px),and total antioxidant capacity(T-AOC)in brain tissue of the mice were measured.Results For the mice in H group,the contents of MDA (3.46±0.29 at the immediate end of exhaustive exercise,2.29±0.55 nmol/mg 24 hours after the end of exhaustive exercise)were significantly lower than those of the mice in N and L group(P<0.01,P<0.05),and the activities of SOD(100.64±10.12,114.58±9.50 U/mg),GSH-Px(2.17±0.35,2.45±0.27 U/mg),and T-AOC(0.50±0.09,0.75±0.09 U/mg)were all higher than those of the mice in N and L group.Conclusion PSP can improve antioxidant capacity of brain tissue and has significant anti-fatigue function in mice.
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  • [1]
    王建治,崔新刚,王海波,等.中药姜黄抗小鼠运动性疲劳作用[J].中国公共卫生,2010,26(8):1028-1029.
    [2]
    辛东,李晖,李静先,等.力竭运动时大鼠脑组织自由基产生及氧化、抗氧化能力的动态观察[J].中国运动医学杂志,1999,18(4):321-323.
    [3]
    王西龙,孙志伟.黄精多糖的研究概况[J].现代医药卫生,2006,22(4):54-55.
    [4]
    王玉勤,吴晓岚,张广新,等.黄精多糖对大鼠抗氧化作用的实验研究[J].中国现代医生,2011,49(5):6-11.
    [5]
    Thomas DP,Marshall KI.Effects of repeated exhaustive exercise on myocardial subcellular membrane structures[J].Int J Sports Med,1988,9(4):257-260.
    [6]
    曹向宇,朱昱,刘剑利,等.小米多肽对小鼠抗疲劳作用[J].中国公共卫生,2011,27(9):1153-1154.
    [7]
    张学会,刘洪珍.复方中药提取物对大鼠不同状态下脑组织自由基代谢影响的研究[J].中国应用生理学杂志,2012,28(2):160-164.
    [8]
    陈瑷,周玫.自由基医学基础与病理生理[M].北京:人民卫生出版社,2002:104-105.
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