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Volume 30 Issue 9
Sep.  2014
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JIAO Feng-ping, LIU Yi-zhi, LI Bao-hua.et al, . Measurement of bone growth factor and its clinical significance in patients with humeral shortness[J]. Chinese Journal of Public Health, 2014, 30(9): 1184-1186. doi: 10.11847/zgggws2014-30-09-24
Citation: JIAO Feng-ping, LIU Yi-zhi, LI Bao-hua.et al, . Measurement of bone growth factor and its clinical significance in patients with humeral shortness[J]. Chinese Journal of Public Health, 2014, 30(9): 1184-1186. doi: 10.11847/zgggws2014-30-09-24

Measurement of bone growth factor and its clinical significance in patients with humeral shortness

doi: 10.11847/zgggws2014-30-09-24
  • Received Date: 2013-04-22
  • Publish Date: 2014-09-10
  • Objective To monitor the levels of seven bone growth factors in humeral shortness patients and normal controls.Methods Peripheral blood of 12 humeral shortness patients and 16 normal controls were collected in Nujiang basin of Tibet.The levels of bone morphogenetic protein-2(BMP-2),bone morphogenetic protein-4(BMP-4),bone morphogenetic protein-7(BMP-7),transforming growth factor-β 2(TGF-β2),fibroblast growth factor receptor-3 (FGFR3),growth differentiation factor-5 (GDF-5),and fibroblast growth factor-23(FGF23) were measured with enzyme-linked immunosorbent assay(ELISA).Results The content of BMP-2,BMP-4,BMP-7,TGF-β2,FGFR3,GDF-5,and FGF23 in humeral shortness patients were 3.35,3.14,568.24,625.09,3.01,3.26 ng/mL,and 161.33 pg/mL,respectively,and those in normal controls were 4.61,3.25,2 300.35,1849.47,5.99,8.09 ng/mL,and 373.47 pg/mL.The contents of BMP-7,FGFR3 and GDF-5 in humeral shortness patients were lower than those of normal controls,and there were significant differences between the two groups.The results of Pearson correlation analysis showed that the seven growth factors were highly correlated in the patient group,while in the normal control group,BMP-2,BMP-4,and TGF-β2 were highly correlated,but the correlations of BMP-7,GDF-5,FGFR3 and FGF23 were weak.Conclusion The causative factor of humeral shortness may be the changes of BMP-7,FGFR3 and GDF-5 and the interactions of various growth factors may affect the mcidence of the disease.
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  • [1]
    李群伟.一种新的骨骼疾病肱骨短小症的报告[J].罕少疾病杂志,2010,17(2):62-63.
    [2]
    李群伟,次央,侯海峰,等.肱骨短小症流行病学调查报告[J].中国预防医学杂志,2012,13(10):721-723.
    [3]
    廖伟雄,李众利,王杰,等.骨性关节炎患者血清和关节滑液中BMP-7的检测及临床意义[J].军医进修学院学报,2012,8(1):34-36.
    [4]
    鹿占成,陈颖,王丽娟,等.检测FGFR3基因鉴别诊断先无性软骨发育不全[J].中国优生与遗传杂志,2003,11(2):16-17.
    [5]
    张勇,刘洪臣.生长分化因子-5(GDF-5)的研究进展[J].中华老年口腔医学杂志,2010,8(2):117-119.
    [6]
    Mikic B,Battaglia Tc,Taylor,et al.The effect of growth differentiation factor-5 deficiency on femoral composition and mechanical behavior in mice[J].Bone,2002,30(5):733-737.
    [7]
    Takahara M,Harada M,Guan D,et al.Development failure of phalanges in the absence of growth differentiation factor-5[J].Bone,2004,35(5):1069-1076.
    [8]
    何希煌,练克俭,翟文亮.骨生长因子对骨形成的协同作用研究进展[J].中国矫形外科杂志,2005,13(20):1582-1583.
    [9]
    田卫东,王大章.生长因子网络调节对骨形成作用的研究[J].华西口腔医学杂志,1998,16(1):65-72.
    [10]
    杜俊杰,罗卓荆,胡蕴玉,等.TGF-增强rhBMP-2 诱导成骨中I、II型胶原mRNA及碱性磷酸酶的表达[J].中国矫形外科杂志,2003,11(24):1696-1698.
    [11]
    石长贵,蔡筑韵,鲍哲明,等.骨生长因子促进骨折愈合研究进展[J].国际骨科学杂志,2010,31(3):184-186.
    [12]
    杨丹,于燕妮.成骨细胞特异性转录因子Osterix研究进展[J].中国公共卫生,2013,29(1):142-145.
    [13]
    次央,央宗,巴桑卓玛,等.西藏大骨节病区藏族居民血清指标检测分析[J].中国公共卫生,2013,29(1):122-125.
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