Relationship between genetic polymorphism of ACE gene and ischemic stroke

ZHANG Zhen-chang; CHEN Li-xia; WU Guo-de.et al

doi:10.11847/zgggws2014-30-09-31

Volume 30 Issue 9

Sep. 2014

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of Public Health > 2014 > 30(9): 1205-1207

ZHANG Zhen-chang, CHEN Li-xia, WU Guo-de.et al, . Relationship between genetic polymorphism of ACE gene and ischemic stroke[J]. Chinese Journal of Public Health, 2014, 30(9): 1205-1207. doi: 10.11847/zgggws2014-30-09-31

Citation:

ZHANG Zhen-chang, CHEN Li-xia, WU Guo-de.et al, . Relationship between genetic polymorphism of ACE gene and ischemic stroke[J]. Chinese Journal of Public Health, 2014, 30(9): 1205-1207. doi: 10.11847/zgggws2014-30-09-31

Citation:

PDF( 926 KB)

Relationship between genetic polymorphism of ACE gene and ischemic stroke

doi: 10.11847/zgggws2014-30-09-31

1.
Department of Neurology, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province 730030, China

Received Date: 2013-04-07
Publish Date: 2014-09-10

Abstract

Abstract

Objective To investigate the relationship between genetic polymorphism of angiotension-converting enzyme(ACE) gene and ischemic stroke.Methods Polymerase chain reaction(PCR)and DNA sequencing were used to detect ACE genotypes in 166 patients with ischemic stroke and 120 healthy controls in a Han population.Results Among the cases with ischemic stroke,the I/D frenquencies of D/D,I/D,I/I were 71.1%,24.7%,4.2%,and that of the controls were 50.8%,41.7%,7.5%,respectively.There were significant differences between the two groups.The relative risk of suffering from ischemic stroke in D/D gene carriers was 2.38 and 2.79 times compared to I/D and I/I gene carriers(95% confidence interval[95%CI] of I/I=1.463-3.872 and 95%CI of I/D=1.914-4.167),and the differences were statistically significant(P<0.05).Conclusion ACE polymorphism is associated with ischemic stroke.The ACE gene D/D allele carriers have a significantly higher risk of ischemic stroke than other genotype carriers and D/D allele may be a genetic susceptibility gene for ischemic stroke.
- angiotension-converting enzyme,
- ischemic stroke,
- gene polymorphism

FullText(HTML)

References(10)

References

[1]	Szolnoki Z,Somogyvari F,Kondacs A,et al.Evaluation of the interactions of common genetic mutations in stroke subtypes[J].J Neurol,2002,249:1391-1397.
[2]	吴艳,张晓雷.4种给药方案治疗急性脑梗死的成本-效果对比研究[J].中国生化药物杂志,2010,31(1):57-58.
[3]	马传武,谢谋华.中西医结合治疗急性脑梗死临床观察[J].中国实用医学杂志,2012,28(12):1014-1015.
[4]	郭淑霞,李娜,丁毓磊,等.哈萨克族居民高血压与ACE和AT1 R基因多态性[J].中国公共卫生,2010,26(3):259-261.
[5]	Tao HM,Shao B,Chen GZ.Meta-analysis of the ACE gene polymorphism in cerebral infarction[J].Can J Neurol Sci,2009,36(1):20-25.
[6]	韩胜红,程锦泉,张岚,等.脂蛋白脂酶D8S282等位基因与缺血性脑卒中关系[J].中国公共卫生,2010,26(2):216-217.
[7]	Bruno A,Saha C,Williams LS,et al.Percent change on the National Institutes of Health Stroke Scale:a useful acute stroke outcome measure[J].J Stroke Cerebrovasc Dis,2009,18(1):56-59.
[8]	Gormley K,Bevan S,Markus HS.Polymorphisms in genes of the renin-angiotensin system and cerebral small vessel disease[J].Cerebrovasc Dis,2007;23(2-3):148-155.
[9]	Baghai TC,Binder EB,Schule C,et al.Polymorphisms in the angiotensin converting enzyme gene are associated with unipolar depression,ACE activity and hypercortisolism[J].Mol Psychiatry,2006,11:1003-1015.
[10]	栗文彬,刘学东,王波,等.缺血性脑卒中短期预后及影响因素分析[J].中国公共卫生,2008,24(4):454-455.