Changes of adrenomedullin level in nutrient obesity rats

  Objective   To observe the changes of adrenomedullin(ADM)level in plasma and heart/weight, liver/weight rate in nutrient obesity rats.

  Methods   The concentration of ADM was determined by special radioimmunoassay, the weight of heart, liver and whole body were measured and the rate of heart/weight and liver/weight(g/g)were calculated respectively.

  Results   The plasma ADM level in obesity rats(78.35±6.38)pg/ml was lower than that in normal rats(92.47±10.61)pg/ml(P < 0.05);the rate of heart/weight(g/g)and liver/weight(g/g)of obesity rats(0.319±0.019), (3.334±0.410)were higher than those in normal groups (0.225±0.020), (2.951±0.730)(P < 0.05).

  Conclusion   Reduction of ADM level probably resulted in the occurrence and progression of nutrient obesity, and probably contributed to the increases of heart/weight and liver/weight.