Association of survivin gene susceptibility and haplotype with hepatocellular carcinoma

To explore the association of rs8073069 and rs1042489 in survivin gene with hepatocellular carcinoma(HCC)in Han population and to provide basis for effective protective measure. Methods Under the design of case-control study,176 Han HCC cases and 196 Han controls were selected in communities of Haimen city,Jiangsu province.Questionnaire survey on basic information was carried out and two loci of rs8073069 and rs1042489 from survivin gene were genotyped. Results The frequency of CC,CG,GG,C and G in rs8073069 was 8.52%,35.22%,56.25%,26.14%, and 73.86% in HCC group and 6.12%,39.80%,54.08%,26.02%,and 73.98% in the control group,respectively.In different genetic models,no statistically significant difference was found in genotype or allele distribution of HCC case group relative to the control group in rs8073069(P>0.05).In HCC group,the frequency of CC,CT,TT,C and T in rs1042489 was 17.61%,55.68%,26.70%,45.45%,and 54.55% and 13.78%,52.04%,34.18%,39.80%,and 60.20% in the control group,respectively.No statistically significant difference was found in rs1042489(P>0.05)either.Multivariate logistic regression indicated that HBsAg positive and the history of hepatitis B were risk factors for HCC.In addition,the haplotype of rs8073069G-rs1042489T was a protective factor for HCC in additive genetic model.However,no haplotype-environment interaction was found in different genetic models(P>0.05). Conclusion Neither rs8073069 nor rs10424892 in survivin gene is associated with the susceptibility of HCC in Han population,but rs9904341G-rs1042489T in survivin gene is a protective haplotype for HCC.