Objective To investigate the association between adenosine triphosphate-binding cassette transporter G2 (ABCG2) gene polymorphism and uric acid level among gout patients in tropical areas and to provide evidences for the warning, diagnosis, and treatment of gout.
Methods Totally 572 gout patients (317 males and 255 females) living in Hainan province were selected at Haikou Municipal People’s Hospital from January 2014 to December 2016 and assigned into a hyperuricemia group and a normal uric acid group according to their blood uric acid level. Whole blood genomic DNA of the participants were extracted and single nucleotide polymorphisms (SNP) of ABCG2 gene rs2231142 were genotyped by a company entrusted. The genotype frequencies of the loci were analyzed with SPSS 19.0.
Results Of the male and female participants, 49.84% (159/317) and 47.47% (134/255) were detected with hyperuricemia, while 50.16% and 52.55% showed normal uric acid level. Genotypes of CA, CC, and AA of ABCG2 rs2231142 gene were detected in the participants, with the detection rates of 51.74%, 29.97%, and 18.30% among the males and 51.37%, 36.08%, and 12.55% among the females, respectively; there were no significant gender differences in the detection rate (P > 0.05). No significant differences were observed in genotype frequency distributions of ABCG2 rs2231142 loci and their allele between male and female participants with hyperuricemia and normal uric acid and between the participants with hyperuricemia and low uric acid level.
Conclusion The polymorphism of ABCG2 rs2231142 is not significantly correlated with blood uric acid among gout patients in tropical areas.
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