Objective To examine the trend in the incidence of atopic dermatitis (AD) and the influence of age, period and birth cohort on AD incidence among residents of China and four developed Asian countries from 1990 – 2019, and to provide a reference for the prevention and control of AD in China.
Methods The data on the incidence of AD among residents of China and four Asian countries ( Japan, Korea, Israel and Singapore) from 1990 – 2019 were extracted from the Global Burden of Disease Study 2019 (GBD 2019) database. Estimated annual percentage change (EAPC) was used to describe country-specific trend in the incidence of AD and an age-period-cohort (APC) model was constructed to analyze effects of age, period and birth cohort on AD incidence.
Results The annual age standardized incidence of AD among residents in China increased from 1990 – 2019 with an EAPC value of 0.0212% (95 confidence interval 95%CI: 0.0077% – 0.0347%). In contrast, the annual age standardized incidence of AD decreased during the 30-year period among the residents of Japan, South Korea, Israel, and Singapore, with the EAPC values of – 0.0433% (95%CI = – 0.0655% – – 0.0211%), – 0.0206% (95%CI: – 0.0380% – – 0.0032%), – 0.0073% (95%CI: – 0.0077% – – 0.0069%), and – 0.0276% (95%CI: – 0.0452% – – 0.0099%), respectively. The results of APC model analysis showed that the residents aged 0 – 4 years and 70 – 94 years were at high risk of AD incidence in China and in the four Asian countries. The risk of AD incidence among the residents in China increased over time but decreased with the year of birth; while, the risk of AD incidence among residents of in the four Asian countries decreased over time but increased with the year of birth.
Conclusion The incidence of AD among residents in China has increased year by year from 1990 to 2019, indicating that in comparison with the situation in the four developed Asian countries, the prevention and control of AD need to be promoted among residents in China, especially among the children and the elderly.
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