Genotoxic Effect of 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone and Its Influence on Lipid Peroxidation on Rats

3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)was administerd to Wistar rats(1.65,165,16500 ng/kg) by gavage one time a day for 15 days.At the end of this period, significant increases of sperm abnormality rate were observed in rats exposed MX at certain doses.Organ index of liver and kidney were changed and pathological changes took place.No signficant increases of micronucleus induction in polychromatic erythrocytes (PCEs)of bone marrow and lipid peroxidation(LPO)level in serum and tissue(live,kidney and testicle)of rats were showed. Our results suggested that MX was able to induce genotoxicity of reproductive cells and to injure the liver and kidney of rats exposed.But no oxidative damage was found.