Effect of Vitamin C Antagonism on Fluorine-induced Inhibition of Antioxidant Enzymes Activities in Human Lymphocyte in Vitro

Objective To study the effect of vitamin C antagonism to fluorine-induced inhibition of antioxidant enzymes activities in human lymphocyte in vitro.Methods SOD,GSH-Px,CAT were determined in human lymphocyte in vitro after adding fluorine or vitamin C and fluorine.Results Three kind of antioxidant enzyme were inhibited with 50μmol/L fluorine;10 μmol/L vitamin C can antagonize fluorine-induced inhibition of SOD,CAT;while 40 μmol/L Vc do the same to GSH-Px.