Study on Familial relevance of Systemic Lupus Erythematosus

ObjectiveTo study the familial relevance of syetemic lupusery thematosus(SLE).MethodTo avoid the confounding effects of population stratification,the independence of transmission of each parental alleles about HLA-DQA1 was tested with the HHRRmethtod for 40 neuclear families.ResultsThe findings revealed significant association between DQA1*0102 and DQA1*0501,of which DQA1*0102 may be a risk factor and DQA1*0501 a protective one(χ²=10.40,P<0.001).ConclusionAs SLE is a complex disease,the relationship of other loci including non-MHCchromso mes to SLEshould be noted according to recent reports.