Preventive Effect of Meglumine on Rat’s Nephrotoxicity Induced by Cisplatin and Discussion on its Mechanism

ObjectiveTo study the effect of Meglumine(NMG)on several correlated parameters in rats exposed by cisplatin(CP),and preliminarily approach its possible mechanism.MethodsThe rats of experimental groups were exposed by CP after the NMG-pretreatment.All rats were killed on 3th or 5th days after treatment.Using different ways to measure the changes of several correlated parameters.The effect of NMG on the antitumor activity of CP was measured in mice bearing S180.ResultsThe ratio of kidney weight to body weight,the level of blood urea nitrogen(BUN),malondialdehyde (MDA)in kidney cortex,and platinum concentration in kidney cortex of experimental groups all lower than those of the CP group rats.The climax of excretion of urinary platinum was advanced to 60-72h from 108-120h.With increase in dose of NMG,the effect of mentioned above was more outstanding.And NMG-pretreatment didn't influence the antitumor activity of CP.ConclusionNMG may prevent renal injury induced by CP and not influence the antitumor activity of CP.To advance the climax of the excretion of urinary platinum and promote the elimination of urinary platinum may be one of the mechanisms.