Effect of Low Concentration of TCE on Human Lipid Peroxidation and Anti-oxidation Enzyme System

Objective To inspect the effects of low concentration of TCE on human lipid peroxidation and anti-oxidation enzyme system.Methods The concentration of TCE in air was determined by gas chromatography,TCA in urine was determined by spectrophotometer,MDA,SOD,ROS,GSH and GSH-PX activit y in serum detected with detection kits respectively.Results The concentration of TCE in air was 31.5mg/m³.The level of SOD of the TCE-exposure group was significant lower than that of the control group(P<0.01),and the levels of the TCA,MDA,ROS,GSH and the activity of GSH-PX of TCE-exposure group were higher than those of the control group.The correlation between the level of SOD and the concentration of the TCA was negative(P<0.01).The correlation between the levels of MDA,ROS,GSH,GSH-PX and the concentration of TCA was positive.Conclusion The exposure to low concentration of TCE may lead to function of lipid peroxidation enhanced,and stimulate the anti-oxidation enzyme system which activity was enhanced.