Study of Fluoride on Kidney Cell Apoptosis in Rat

Objective To study effects of fluride on apoptosis of kidney cells of rats.Methods Wistar rats were provided with distilled water containing NaF(50mg/L)for six months.Kidney cell apoptosis were detected by TUNEL(TdT-mediated dUTP Nick End Labelling)and flow cytometry.Results TUNEL-positive cells could be detected in fluoride-treated rat kidney,the apoptotic rates of fluoride-treated kidney cells were higher than those of the control significantly.Conclusions This result indicated that fluoride could induce kidney cells apoptosis of rats.