Observation on Immunologically Cell Competence of Pregnant Women with Iron Deficiency

ObjectiveIn order to review the changes in cellular immune function in pregnant women with iron deficiency.MethodsT lymphocyte subsets level(CD₃⁺、CD₄⁺ and CD₈⁺)and nature kill cells activity(CD16)were determined in 128 iron deficiency pregant women,52 normal prenant women and 50 women before pregnancy were examined.ResultsThe level of T lymphocyte subsets,percentages of CD₃⁺ and CD₄⁺ cells as well as the ratio of CD₄⁺/CD₈⁺ cells in the pregnant women were signficantly lower than that of those non-pregnant women.During pregnancy,with the increase of iron deficiency,the percentages of CD₃⁺ and CD₄⁺ cells in bodies of pregnant women decreased.The pregnant women of iron deficiency anemia (IDA)reduced percentages of CD₃⁺ and CD₄⁺ cells as well as the ratio of CD₄⁺/CD₈⁺ compared with normal pregnant women (P<0.01,P<0.05,P<0.05);The percentage of CD 16 in pregnant women of IDA was lower than that of normal pregnant women,but no significant change.ConclusionThere was significant effects of iron deficiency on T lymphocyte subsets level during pregnancy.The relationship between iron deficiency and nature kill cells activity needed to be studied further.