Objective To explore the effect of chronic lead exposure on the mRNA expression of bcl-2 and bax in hippocampus of mice.
Methods RT-PCR techniques were applied to recognize either the mRNA expression of bc-2 and bax in hippocampus of mice exposed to low level of lead.
Results Bcl-2 mRNA expression in Pb2+-exposed group exhibited a significantly decline and bax mRNA expression in Pb2+-exposed group exhibited a significantly increase compared with control group.
Conclusion Chronic lead exposure results in significant decline of bcl-2 mRNA expression and significantly increase of bax mRNA expression in hippocampus of mice.