Meta analysis on relationship between PCBs and human breast cancer

  Objective   To analyze relationship between polychlor inated biphenyl(PCBs)exposure and breast cancer.

  Methods   13 research reports of case-control studies were collected.Meta analysis method was used to analyze total ORs.A fixed effect model(FEM)or a random effect model(REM)was chosen to calculate total ORs depending on the results of the test of homogeneity(Qtest).Three subgroups, including source of biomaterials, menopausal status, and polymorphism of CYP1A1 gene, were analyzed to explore heterogeneity.

  Results   The Q value for the test of homogeneiy of the 13 reports was 23.33(P < 0.05).The value of ORDL calculated by REM was 1.05(95%CI, 0.99~1.20).The results of subgroup analysis showed five subgroups were homogeneity(P > 0.05).Values of total ORs of the subgroups of premenop ausal, CYP1A1 gene mutation were 1.40(95%CI, 1.01~1.96)and 1 89(95% CI, 1.21~2.97)respectively.

  Conclusion   Premenopausal women with PCBs high exposure may be a high-risk population for attacking breast cancer.Subg roup with variant genotypes of CYP1A1 may be the susceptible population for PCBs exposure.