Expression of CD44v6 protein associated with prognosis in colorectal carcinoma

  Objective   To investigate the relationship between expression of CD44v6 and prognosis of colorectal carcino ma(CRC).

  Methods   The expression of CD44v6 in 120 CRC cases was detected by Streptavidin-Peroxidase immunohisto chemical technique.

  Results   The positive expression rate of CD44v6 in CRC was 31.7% (38/120).The positive expression of CD44v6 in CRC was significantly associated with lymph nodes metastasis and Dukes stage(P < 0.05).The positive expression rate of CD44v6 in CRC withly mph nodes metastasis was significantly higher than that without lymph nodes metas tasis; the positive expression rate of CD44v6 was gradually increasing when Dukes stage deeping.CD44v6 expression was correlated to survival time of CRC cases(P < 0.01).

  Conclusion   CD44v6 expression in CRC is associated with Dukes stage, lymph nodes metastasis and survival time of CRC cases.CD44v6 is a prognostic factor of CRC probably.