Relationship between ACE gene and metabolic syndrome and hypertension in Mongolian population

  Objective   To explore association of polymorphism of ACE gene with high lipid and insulin resistance on hypertension in Mongolian population.

  Methods   On basis of a cross sectional study, 450 hypertensives and 590 nomotensives were recruited as the subjects to test blood lipid, blood sugar, insulin and polymorphism of ACE gene.

  Results   Frequency of genotype ID in hypertensives was significantly higher than that in no motensives(P < 0.05).In populations with genotype and ID, odds ratio(OR)of group with ISI < -2.81 to group with ISI≥-2.81 for hyper tension were 2.23 and 1.94, respectively.

  Conclusion   The Mongolian population with low insulin sentivity could increase their risk for hypertension, and further, genotype IDplus insulin resistance would exert a synergetic effect on hypertension.