Study of Purslane Herb on anti-hypoxia and its probable mechanism

  Objective   To investigate the effects of Purslane Herb aqueous extracts(PHAS)on anti-hypoxia ability of mice.

  Methods   The survival time to hypoxia of the mice treated with different doses of PHAS and saponins panax ginseng were observed.The activities of Phosphohructokinase(PFK), Pyruvate kinase(PK), Na⁺, K⁺-ATPase, Ca²⁺, Mg²⁺-Atpase and lactate dehydrogenase(LDH), and contents of ATP and lactic acid in the cardiac myocytes and brain celles were tested.

  Results   As compared with hypoxia model group, three doses of PHAS(0.5, 1.0 and 2.0 ml/d)and saponins panax ginseng prolonged the survival time to hypoxia, and the 1.0 ml/d PHAS had the best effect.In the group of 1.0 ml/d PHAS, the activity of PFK, P K, Na⁺, K⁺-ATPase, Ca²⁺, Mg²⁺-ATPese, and LDH decreased less, and contents of ATP was higher significantly.

  Conclusion   PHDS can lengthen the survival time of hypooxia stressed mice.One of its mechanisms may be accelerating the activity of the key enaymes in glycolysis.