Effects of lead and ethanol on cell immunization in male mice

  Objective   To study the effects and mechanism of lead and ethanol on the cell immunization of male mice.

  Methods   The effects of lead and ethanol by the spleen visera coefficient were studied, Tlymphocytes were determined by blastogenic response imduced by the mitogen, concanavalin A(ConA), of spleen lymphocyts as well as glutathione and lipid peroxidation of the spleen in the male mice.

  Results   Tly mphocytes were determined by blasto genic response imduced by the mitogen, concanav alin A(Co nA)was decreased in all ex perimental groups.The content of LPO was increased in all experimental groups.

  Conclusion   Lead and ethanol may affect the cell immunization of male mice with joint effect and could be related to the lipid peroxidation.