Effect of anthocyanin-rich extract from black rice on stability of atherosclerotic vulnerable plaque

  Objective   To explore the role of anthocyanin-rich extract from black rice on anti-atherosclerosis.

  Methods   Atotal of 48 ApoE ^-/-mice on a C57BL/6J back ground were fed with a chow diet based on American Institute of Nutrition93 purified diets for laboratory rodents(AIN-93)for 30 weeks to establish vulnerable plaque model.Then the mice were randomly divided into three groups: anthocyanin-rich extract from black rice group, simvastatin group and control group.The animals were fed different diets for 20 weeks, then the changes of vulnerable plaque in innominate arteries were observed and the blood was determined for lipids.

  Results   Compared with control group, levels of serum TG, total cholesteral(TC), low-density lipoprotein cholesteral(LDL-C), high-density lipoprotein cholesteral(HDL-C)were all significantly decreased in anthocyanin-rich extract from black rice group and simvastat in group(P < 0.05).And there is no difference in LDL-C/HDL-C among three groups.The frequency of vulnerable plaque in innominate arteries was lower and the relative plaque area was smaller, decreased by 15.77% and 14.72% separately, in anthocyanin-rich extract from black rice group and simvastatin group than in control group.But there was no significant difference in total anti-oxidant capacity(T-AOC)among three groups (P > 0.05).

  Conclusion   Similar to simvastain, anthocyanin-rich extract from black rice can promote the stability of advanced plaque in old ApoE ^-/- mice, which may contribute to modulate lipid metabolism, not the anti-oxidate capability.