Alteration of immune factors in both IDA pregnant women and their cord venous blood

  Objective   To observe and evaluate the changes in immune factors of the iron deficiency anemia(IDA)pregnant women.

  Methods   The serum IL-2, IgA, IgG, IgM and complement C3 were determined in 63 IDA pregnant women, 50 normal pregnant women and their cord venous blood.These parameters were also determined in 50 non pregnant women.

  Results   The serum IL-2 level of the pregnant women was significantly higher than that of those non pregnant women(P < 0.05).The levels of serum IL-2 and IgG in the IDA pregnant women were significantly lower than those of normal pregnat women(P < 0.01;P < 0.01).The levels of IL-2 and IgG in pregnant women had a positive correlation with those of their cord venous blood(r=0.741 79, P < 0.05, r=0.828 50, P < 0.05).Compared with cord venous blood of normal pregnant women, the level of IgG of the IDA pregnant women was distinctly decreased and the IgM level was distinctly increased(P < 0.01).

  Conclusion   The IDA during pregnancy has evident effects on the level of serum IL-2 and IgG as well as effects on parameters of cord venous blood.