Study on relationship between sTNFR2 and insulin resistance in DIO rats

  Objective   To study the relationship between serum soluble tumor necrosis factor receptor 2(sTNFR2)and insulin resistance(IR)in diet-induced obesity(DIO)rats.

  Methods   The level of serum sTNFR2 was determined by enzyme linked immunosorbent assay(ELISA).The concentrations of serum tumor necrosis factor A(TNF-а)and fasting insulin (FINS)were measured by radioimmunoassay.

  Results   The levels of sTNFR2 and TNF-а of DIO rats were significantly higher than those of the controls and die-tinduced obesity resistant(DIO-R)rats(P < 0.01).Insulin sensitivity index(ISI) was in stongly negative correlation with the levels of serum sTNFR2 and TNF-а in DIO rats(P < 0.05).

  Conclusion   sTNFR2 may play an important role in IR related to obesity.