Objective To investigate the effects of human parathyroid hormone related protein(PTHrP1-34)on the osteoporosis of ovariectomized rats.
Methods 60 female 4-mont-hold Wistar rats were used for this experiment and 40 of them were ovariectomized and another 20 received sham operation.After 6 weeks of ovariectomy the osteoporosis model was confirmed by use of 10 ovariectomized and sham-operated rats.The osteoporotic rats of 30 were randomly divided into 3 treatment groups, i.e.PTHrP, Estradiol and Placebo.The bone mineral density(BMD), serum Ca, P, alkaline phosphatase(ALP), tumor necrosis facto-rA(TNF-α), bone-carboxy glutamate protein(BGP)and I nsulin-like growth factor-Ⅰ(IGF-1)were measured after 3 months therapy.
Results After 12 weeks.treatment the femoral and lumbar BMD in the PTHrP group were increased obviously compared with those of Placebo groups.After treated with PTHrP, serum BGP and IGF-1 significantly increased compared with those of Placebo groups, and serum TNF-αhadn't any change.
Conclusion PTHrP1-34 can stimulate osteoblast activity, promote bone mass effect and is effective on protection against osteoporosis.
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