Antagonistic effects of sea buckthron oil and Na2SeO3 on rats exposed to mercuric chloride

  Objective   To study the liver and renal toxicity induced by mercury and to observe the effects of Seabuckthom seed oil(SBO), Na ₂SeO ₃ pretreatment on the liverotoxicity and nephrotoxicity of mercury.

  Methods   Wistar rats were divided randomly into control group, mercury group and SBO, Na ₂SeO ₃ pretreatment groups.The 12h urine samples and the blood samples were collected, The liver and renal cortex were also removed.Mercury contents in the liver, renal cortex and urine samples were measured.Urinary Nacety-l B-D-glucosaminidase(NAG), alkaline phosphates(ALP), lactose dehydrogenase(LDH)activities, urinary protein and serum urea nitrogen(BUN)contents were also determined.

  Results   Mercury contents of urine of SBO pretreatment group were higher significantly than that of 2.5 mg/kg HgCl ₂ group.Mercury contents in the liver of Na ₂SeO ₃ pretreatment group were higher than that of 2.5 mg/kg HgCl ₂ group, Mercury concentrations in renal cortex and urine, Urinary NAG, ALP, LDH activities, urinary protein and BUN contents were lower significantly than that of 2.5 mg/kg HgCl ₂ group.

  Conclusion   SBO and Na ₂SeO ₃ had antagonistic effects on liverotoxicity and nephrotoxicity of mercurty.