Study on reminiscent responsion of Hepatitis B vaccine booster immunization in 3~12 years-old children of Beijing

  Objective   To evaluate the character of the reminiscent responsion of the Hepatitis B vaccmebooster immunization on the children who were anti-HBs negative in Beijing.

  Methods   The multiple stratified cluster sampling was used in this epidemiological survey.The sampling children's blood serum HBsAg, antiHBs and antiHBc were checked and measured by the Solid Phase Radioimmunoassay(SPRIA).The children whose antiHBs serological titer(GMT)was lower than 10 Iu/L had the Hepatitis B vaccine booster immunization in two different dosages.

  Results   2 419 3~12 years-old children who were immunized by the Hepatitis B vaccine in the infant period were surveyed and the total anti-HBs negative rate was 48.25% (CI%, 35.15~64.26).725 children had the Hepatitis B vaccine booster immunization and the antiHBs positive rate was observed.The antiHBs positive rate of the children who were immunized in 2.5 μg and 5.0 μg Hepatitis B vaccine was 90.6% and 90.9% respectively.The GMT was 85.69 and 87.59 Iu/L respectively.The antiHBs positive rate was also analyzed according to the different time of the blood sampling.And there were both no statistical significances between the two dosages(χ ²=0.02, P=0.89; t=0.36, P=0.72).The average antiHBs positive rate was 92.80% and the GMT was 84.55 Iu/L after 4~5 weeks.The average antiHBs positive rate was 86166% and the GMT was 91.39 Iu/L after 6~22 weeks.There were statistical significance for the average antiHBs positive rate(χ ²=7.47, P=0.006)and no statistical significance for the antiHBs GMT between the different blood samplmg time(t=1.09, P=0.28).

  Conclusion   For the 3~12 year-sold children who had finished the basic immunization of Hepatitis B vaccine in the infant period, a little dose of Hepatitis B vaccine could make responsion strongly in their bodies after the antibody died away.It showed that there was remimscent responsion for the Hepatitis B virus in their bodies.This reminiscent responsion could be the main cause that made people have the long-term protection of Hepatitis B vaccine.