Expression of lymphocyte surface CCR5 in HCV and HIV infection

KANG Hui; WANG Yanan; FAN Xia

doi:10.11847/zgggws2006-22-04-24

KANG Hui, WANG Yanan, FAN Xia, . Expression of lymphocyte surface CCR5 in HCV and HIV infection[J]. Chinese Journal of Public Health, 2006, 22(4): 421-422. DOI: 10.11847/zgggws2006-22-04-24

Citation:

KANG Hui, WANG Yanan, FAN Xia, . Expression of lymphocyte surface CCR5 in HCV and HIV infection[J]. Chinese Journal of Public Health, 2006, 22(4): 421-422. DOI: 10.11847/zgggws2006-22-04-24

Citation:

KANG Hui, WANG Yanan, FAN Xia, . Expression of lymphocyte surface CCR5 in HCV and HIV infection[J]. Chinese Journal of Public Health, 2006, 22(4): 421-422. DOI: 10.11847/zgggws2006-22-04-24

Expression of lymphocyte surface CCR5 in HCV and HIV infection

Abstract

Abstract

Objective To investigate expression and significance of CC-chemokine receptor 5(CCR5)in HCV monoinfection, HIV mono-infection and HCV/HIV co-infection.
Methods The surface expression of CCR5 on CD4+ Tcells and CD8+ Tcells from PBMC isolated from HCV infection(n=21), HIVinfection(n=14), HCV/HIV co-infection(n=28)and normal control(n=30)by flow cytometry.
Results The expression of CCR5 on CD4+ and CD8+ T lymphocytes increased significantly in HIV mono-infection(P < 0.01), but decreased significantly both in HCV mono-infection and HCV/HIV co-infection(P < 0.01).
Conclusion The surface expression of CCR5 on lymphocytes increased with HIV infection, decreased with HCV infection.In HCV/HIV co-infection, HCV maybe effect on the expression of CCR5 on lymphocytes.

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