Analysis on risk factors of insulin resistance clustering in type 2 diabetes mellitus families

  Objective   To explore the relationship between insulin resistance and the clustering of Cardiovascular Disease (CVD)among relatives of T2DM family and health people.

  Methods   115 T2DM families were selected, which contained 268 cases as the case group, 302 relatives but nondiabetic individuals from these families as the inner control group and 161 healthy ones as outer control group that contained 570 subjects in all.Chi-test and binary logistic reg ression were used.

  Results   Insulin resistance and risk-factor clustering had association among these three groups(All P < 0.05).Then what insulin resistance was the base of clustering of CVD in multiple familial type 2 diabetes mellitus was uncovered.The value of OR increased with the value of HOMA-IR growing.The mean of insulin secretion in inner-group was higher than that of both T2DM group and outer-group(P=0.018, 0.000).

  Conclusion   Whether the individuals in relative group in families with type 2 diabetes orin the health group all have severe insulin resistance before getting CVD.However, their Bcells could secrete instead of dysfunct ion of insulin resistance as a prevention.And cardiovascular risk factors clustering may be the reason of type 2 diabetes mellitus.Insulin resistance may be the basis of multiple familial type 2 diabetes mellitus.