Relationship between LRP5 and VDR genes polymorphism and bone mineral density in Harbin men

  Objective   To investigate the association of LRP5 gene Q89R, A1330V and VDR gene Fok' polymorphism with bone mineral density(BMD)in Harbin Men.

  Methods   132 unrelated healthy men of Han nationality, aged 20~55 from Harbin, were selected.Dietary calcium intakes, serum biochemistry, serum hormones, bo ne mineral density were measured by dual energy X-ray, densitometry were assessed in all subjects.The polymorphisms of LRP5 gene and VDR gene were determined using PCR-RFLP.

  Results   It failed to find that the values of serum biochemistry and serum hormones were different statistically among genotypes.There was a significant association between Q89R and adjusted bone mineral density (BMD)at Femoral neck(NECK)(P=0.047), and a marginal association was observed at Wardcs triangle(WARD)(P= 0.073)and trochanter(TROCH)(P=0.081).Neither Fok' nor A1330V genotypes was significant association with BMD after adjusting other factors at any skeleton sites.There were not interactions for BMD among three genotypes.

  Conclusion   LRP5 gene Q89R poly morphism influence on BMD at NECK in Harbin men.