Genetic gene polymorphisms and interactions of hypertension in Mongolian people

  Objective   To explore the association between RASsystem genes(AGT, ACEand AT1R)polymorphisms, genes interaction and hypertension in Mongolian people.

  Methods   On basis of prevalence study, a case-control study with 299 hypertensives and 281 nomotensives was conducted.The subjects' general information was acquired by questionnaire, and their fast venous blood samples were collected at the same time.6 single nucleotide polymorphisms of RASsystem genes were genotyped by polymerase chain reaction/restriction fragment length polymorphism and polymerase chain reaction/single strand conformation polymorphism.

  Results   There were no significant differences to be found between cases and controls for genotype frequencies or allele frequencies of the 6 polymorphisms of RASsystem, except in male group, ORvalue of men carried ACEID+DDgenotype vs.men carried IIgenotype was 2.20(95% CI: 1.21~4.02).Interaction analysis found that people who carried both ACEID(or DD)and AGTM235 TMT(or MM)had more risk to have hypertension.

  Conclusion   ACEgene ID+DDgenotype is the risk factor of hypertension in male group.