Relationship between polymorphism of E-cadherin gene and genetic susceptibility of non-cardia gastric cancer

  Objective   To test the hypothesis that a C to A variant in promoter of E-cadherin gene, which is associated with risk of developing non-cardia gastric cancer.

  Methods   Population based case-control study was used and the polymerase chain reaction-restriction fragment length poly morphisms(PCR-RFLP)was used to genotype this variant in 207 non-cardia gastric cancer patients and 270 age-sex frepuency-matched cance-rfree controls.

  Results   The distributions of CDH1 genotypes were not significantly different between cases and controls(χ²=01 29, P=0.87).Compared with the CC genotype, the variant CA and AA genotypes were not associated with an increased risk of gastric canceradjusted odds ratio(ORa)were 1.15, 0.90 respectively; 95% confidence interval(CI)were 0.87-1.72, 0.42-2.01 respectively.

  Conclusion   The C160a promoter polymorphism of E-cadherin gene may not play a major role in the etiology of non-cardia gastric cancer.