Inhibition effect of grape procyanidin on proliferation of breast carcinoma cell

  Objective   To study the inhibition effect of grape procyanidin(GPC)on the proliferation of breast carcinoma cells.

  Methods   Different dose of GPC was given by mouth to the mice inoculated EMT 6 breast carcinoma cells.The proliferation of brease carcinoma cells was determined by methy 1 tetrazolium(MTT)assay, and the proliferation cell nuclear antigen (PCNA)and mutant p 53 protein expression of mice breast carcinoma cells was measured by immunohistochemistry method after 13 days.

  Results   The expression rates of RCNA and mutant p53 protein of the carcinoma control group were 721.28% and 371.22% respectively, and those of the high dose GPC group were 28.32%and 7.46%.The differences between the two groups were significant(P < 0.05).The proliferation of mice breast carcinoma cells offered reducing tendency with the increasig dose of GPC indifferent groups.

  Conclusion   GPC has an inhibition effect on the proliferation of the breast carcinoma cells.