Damaging effects of dust storm fine particles instillation on DNA in lung cells of rats

  Objective   To investigate damaging effects of dust storm fine particle(PM2.5)on DNA in lung cells of rats.

  Methods   Wistar rats were randomly divided into toxicosis groups and control group by intratracheal instillation.After instilled 24 hours, DNA damage of lung cells of rats was detected with single cell gel electrophoresis technique.

  Results   Both dust storm PM_2.5 and normal weather PM_2.5 could lead to DNA damage in a dose-dependent manner.Though the effects induced by normal weather PM_2.5 heavier than dust storm PM_2.5, there was no significant difference between them.

  Conclusion   Both dust storm PM_2.5 and normal weather PM_2.5 could lead to DNA damage in lung cells of rats.However, the dust storm PM_2.5 whose airborne concentrations were much higher than that of normal weather PM_2.5, so the dust storm PM_2.5 should be more harmful.