Biological safey evaluation of modified PPC as a new biodegradable material

  Objective   To make a new biodegradable material, polypropylene-carbonate(Modified PPC)and to evaluate its biological safety.

  Methods   Modified PPC was a new biodegradable material generated by mixing of PPC and poly β-hydroxybutyrate(PHB).The evaluation experiments included: acute toxicity test, pyrogenic test, cell toxicity texted by methyl thazolyl tetrazolium(MTT)assaying, hemolysis test and skin stimulation test.

  Results   Modified PPC had no generaltoxic reaction, no heat source, no cytotoxicity, no skin simulation and had favourable blood compatibility.

  Conclusion   Modified PPC has satisfactory biological safety.