Effect of aluminum chelating agent on liver zymogram and on essential elements of rats induced by aluminum

Objective To inquire into the effects of 1,2-dimethyl-3-hydrox ypyrid-4-pyridine(DHPO)on alanine aminotransferase(A ),glutamicox alacetic transaminase(AST),and alkaline phosphatase(ALP)in serum and elements aluminum(Al),zinc(Zn),copper(Cu),iron(Fe),calcium(Ca)and magnesium(Mg)in liver of rats induced by aluminum.Methods Wistar rats were administered with aluminum chloride for 3 weeks.Then they were treated with different doses of DHPO.T he activ ity of ALT,AST and ALP in serum was detected,and the concentrations of Al,Zn,Cu,Fe,Ca and Mg in liver tissue were measured.Results The result of ALT activity demonstrated that there was nostatistical significance among all the groups(P>0.05).The AST activity of low,moderate and high DHPO dose groups was lower than the positive control(P<0.01).The result of ALP activity indicated that the low DHPO dose group was significantly different from the positive control(P<0.01).The aluminum concentration of the three different dose groups was significantly lower than the positive control(P<0.01).Compared with the negative control,the Zn,Cu,Fe,Ca,Mg concentrations of the moder ate and high DHPO dose groups were not significantly different(P>0.05).Conclusions DHPO could effectively enhance the elimination of Alin liver,but dose not affect the excretion of Zn,Cu,F e,Ca and Mg.DH PO can recover the activity of AST and ALP in serum being damaged by aluminum in some degree.