Mutagenicity by combustion particulates from LPG and coal and their joint action

ObjectiveTo compare the mutagenicities by combustion particulates from liquefied petroleum gas(LPG)and coal,and to know the model of their joint action.MethodsAmes test was applied.The bacterial strains used were Sal monella typhimurium TA 98 and its two derivation strains YG1021 and YG1024.ResultsThe mutagenicity by LPG combustion particulates was about eight times as high as that by coal.The joint action model of two combustion particulates was additive effect.ConclusionBoth LPG and coal combustion particulates contain strong direct and indirect-acting mutagens,the mutagenicity is mainly induced by nitroarenes and aromatic amines.Concurrence of combustion particulates will increase the risk of carcinogenesis.