Effects of canthaxanthin on antioxidantive action in D-galactose induced aged rats

ObjectiveTo study the influence of canthax anthin on the antio xidantive function of D-galactose induced agingrat.MethodsTo cause aging,Wistar rats were given injections of D-galactose for 5 months.Then they were randomly divided in four groups,including model group,low-does canthaxanthin group,middle-does canthaxanthin group and high-does canthax anthin group whose the content of malonic aldehy de(MDA)and the activity of superoxide dismutase(SOD) and glutathione perox idase(GSH-Px)of different viscera(liver,kidney,heart,brain,prostates,etc)were tested and compared.ResultsCompared with model group,the content of MDA in the canthax anthin group had statistical significance and to be significantly decreased(P<0.01).However,the activity of SOD and GSH-Px had statistical significance and to be significantly raised(P<0.001).ConclusionCanthax anthin can increase antiox idantive function of rat to stay D-galactose induced consenescence.