Effects of new chelating agents on testicular toxicity in mice induced by acute exposure to cadmium

ObjectiveTo study the effects of new chelating agents N-p-hydroxy-methyl-benzyl-D-glucamine dithiocarbamate(HBGD)and N-benzyl-D-glucamine dithiocarbamate(BGD)on testicular toxicity in mice induced by acute exposure to cadmium.MethodsHBGD,BGD,diethyldithiocarbamate(DDTC),2,3-dimercaptopropanol(BAL),and ethylene diaminetetraacetic acid(EDTA)were studied for theireffects on the concentrations of cadmium(Cd),calcium(Ca), iron(Fe),and zinc(Zn)in testes,lipid peroxidation(LPO)value of testes,activity of lacatate dehydrog enase(LDH)in serum and reproductive ability of male mice induced by acute exposure to Cd.ResultsMice were injected intraperitoneally with CdCl₂(2.5 mgCd/kg)and after 30 min or 24 h,they were injected intraper itoneally with chelating agents(400 μmol/kg).Cd injection increased in the concentrations of Ca,Cd,Fe,Zn,and LPO value in testes as well as the activity of LDH in serum of mice.HBGD and BGD effectively prevented the increase in above indices,and clearly improved the reproductive ability weakened by exposure to Cd.ConclusionHBGD and BGD are not only more effective detoxificationon testicular toxicity in mice induced by acute exposure to Cd,but also less toxic,so they are pretect antidote for Cd.