Single nucleotide polymorphisms in XRCC1 and outcome in gastric cancer patients receiving oxaliplatin based chemotherapy

Objective To investigate whether the single nucleotide polymorphism(SNP)in DNA repair gene XRCC1 (X-ray repair cros-sco mplementing 1)were associated with the survival of 5-FU/oxaliplatin combination chemotherapy in gastric cancer.Methods Overau survival time of 62 gastric cancer patients receiving platinum-based chemotherapy were investigated.XRCC1 genot ypes were assessed using 5c nuclease allelic discrimination assay(TaqMan)using real-time PCR.Results The median sur vival time of all 62 gastric patients was 461 days.The median surv ival time of patients with Arg/Arg or Arg/Gln genoty pes was 490 days compared with 295 days of others(P=0.022).Conclusion XRCC1 399 SNP was predictive marker of survival for gastric cancer patients receiving platinum-based chemotherapy.