Association of administration of hepatitis B immunoglobulin during pregnancy with intrauterine infection of HBV

Objective To explore the protective effect of HBIG administrated during pregnancy against HBV intrauterine infection and its candidate mechanism.Methods 210 HBsAg positive pregnant women who were consecutively collected and were administered with HBIG were selected as intervention group.402 consecutively collected HBsAg positive pregnant women who were not administered with HBIG were selected as controls.Incidence of HBV intrauterine transmission was compared between 2 groups.Titer of HBsAg and copies of HBV DNA in maternal sera of intervention group were detected for explorating its considerate mechanism.Results Ten neonates in intervention group and 15 in control group were detected as occurrence of HBV intrauterine infection and the difference was non significant by Chi-square test.There were no significant relation between titer of HBsAg or copies of HBV DNA and frequency of HB IG administration with R-value 0.039 or 0.012 respectively(P>0.05).Conclusion HBIG administration during pregnancy didn't decrease the titer of HBsAg and copies of HBV DNA,and the protective effect on HBV intrauterine infection was not found.