Effect of soy isoflavone on bone density of menopause females

Objective To study the effect of soyisoflavene on menoppause females and their bone mineral density by means of intervention tr ails.Methods 90 menopause females were selected,then divided into two groups,each of them took is of lavone 90mg/d or placebo for 6 months.Their bone mineral of radius and tibia were measured by ultrasoud and IL-6 and TNF-α were measureed by ELISA method.Results The tibia mineral of isoflavone group increased significantly,but that of the control group didn't change;The level of IL-6 and TNF-α of isoflavone group decreased signficantly after trail fin ished.Conclusion Soy isoflav one can increase menopause females'bone mineral and the mechanism maybe is the decreasing the level of IL-6 and TNF-α.