Effects of soy isoflavone on reproductive system of male rats

Objective To explore the effects of prenatal soyisoflavone exposure on reproductive system of offspring male rats.Methods 40 preg nant rats which mated with male rats according to 2:1 ratio,were divided into four groups randomly.Soy isoflavone was conducted to the pregnant rats by garage(peanut oil.worked as solution,was delivered to control group) during the period of E13~E19.F1 male rats were sacrificed on 90^th day.Results The measured indices of F1 male rats in the 150 and 450mg/kg soy isoflavone exposure groups were:aver age testis weights 2.68 and 2.16g,alkaline phosphatase activities 1078.88 and 1058.88 U,levels of lactate dehydro genase 2 678.88 N and 529.38 U,sperm motility 20.12% and 24.13%,sperm counts in the tail of epididymis 50×10⁶/g and 40.5×10⁶/g,sperm productions per day 19.4610⁶(g·d)and 16.2110⁶/(g·d)respectively.All indices mentioned decreased significantly compared with those in the control group and showed does-effect relationship with soy isoflavone.Conclusion High dose of soyisoflavone exposure might bring hazards to the F1 male reproductive system in differentiation period of reproductive system.