Protection of ultraviolet blood irradiation and oxygenation against peroxidative damage induced by soman in rabbits

Objective To study the effect of peroxidative damage induced by soman in rabbits and the protection of ultraviolet blood irradiation and oxygenation(UBIO).Methods One hundred health rabbits were randomly divided into five groups including normal control,intoxication,routine therapy,UBIO therapy and UBIO combined routine therapy(compound therapy)group.Fourteen days after intoxication,the activities of superoxide dismutase(SOD),total antioxidative capacity(TAOC)and contents of malondiadehyde(MDA)of sera and livertissues were determined respectively.Results The serum and liver T-AOC,SOD activities in intox ication group(5.6±1.6),(187.6±50.1)KU/L;(2.06±0.26),(12.30±2.19) KU/(·)were significantly lower compared with normal control group(7.6±2.4),(233.2±24.4)KU/L;(2.53±0.27),(20.95±4.34)KU/(·)(P<0.01),but the MDA contents(0.11±0.11)mol/L;(2.65±0.12)mol/(g# prot)were significantly higher than that of normal control group(0.08±0.02)mol/L;(1.38±0.15)mol/(·)(P <0.01).After UBIO or compound ther apy,the activities of T-A OC and SOD in sera and liver tissues(7.6±1.4),(229.4 ±0.7)KU/L,(2.63±0.35),(24.05±4.66)KU/(·);(7.5±1.8),(230.0±24.7)KU/L,(2.67±0.35),(25.29 ±3.58)KU/(·)were significantly increased compared with that of intoxication group(P<0.01).But the MDA contents(0.08?0.01)mol/L,(0.08?0.01)mol/(·)were obviously lower than that of intox ication gr oup(P< 0.01).Conclusion Soman intoxication have obviously peroxidative damages in rabbits and UBIO therapy have significant protection effect,so it can be used as a treatment or adjuvant treatment for acute soman intoxication.