Relationship between serum adiponectin and insulin resistance in obese adolescents

Objective To study the relationship betw een serum adiponectin and insulin resistance in obese adolescents.Methods Height and body weight were ex amined in 940 students of 13~14 years-old.47 were selected as the obese group (BMI were>=95th percentile of age-and sex),and 50 as control group.Blood pressure,fasting blood glucose,insulin and serumadiponect in were determined,and HOMA-IR was calculated.The subjects.body composition was measured by dual energy V-ray absorption(DEXA).Results There were significant differences between two groups in blood pressure(P<0.05),BMI(P<0.01),HOMA-IR(P<0.01),trunk fat(P<0.01)and serum adiponectin(P<0.05).In ageneral multivariate regression,trunk fat and HOMA-IR were significantly independent deter minants for serumadiponectin concentration.Conclusion Serum adiponectin of obese adolescents were lower and negatively correlated to body fat and insulin resistance.