Research on genotoxicity of bactericide flutriafol

Objective To study the genotoxicity of bactericide flutriafol.Methods The Ames test,micronucleus test and comet assay were used to detect the g enotoxicity of bactericide flutriafol.Results With and without S9 activation,there were negative results of the TA97,TA98,TA100 and TA102 str ains in A mes test.The micronucleus rates in all doses were not significantly different from that of the control group.For the tail DNA% of comet assay there was a significant difference between the negative control and the treated group(P>0.05)in dose of 80 mg/(kg·bw),while there was no significant difference between the negative control and the treated groups(P<0.05)in other dose.The results of genetic toxicity tests were all negative.Conclusion The bactericide flutriafol had no genetic toxicity in this test.