Association of oral contraceptives and ACE gene polymorphisms on risk of hypertension in Chinese women：a case-control study

Objective To evaluate the association of oral contraceptives(OC)use and angiotensin(ACE)gene polymorphisms on the risk of hypertension in Chinese women.Methods We included 665 female hypertensive cases and 665 female controls free from hypertension.All controls were matched with cases on age(±3 years)and residence.The restricted fragment length polymorphsm-polymerase chain reaction(RFL P-PCR)was used in genotype assay.Results The genotype distribution of I/D and A2350G polymorphisms were similar between hype rtensive cases and controls.Compared with non-OC users with ID+DD genotypes,women carried ID+DD genotypes with OC use for at least 15 years had a significantly increased risk of hype rtension(OR=1.66,95%CI=1.11-2.48).Meanwhile,compared with non-OC users with AG+GG genotypes,women carried AG+GG genotypes with OC use for at least 15 years had a significantly increased risk of hype rtension(OR=1.66,95%CI=1.09-2.54).Conclusion Dallele of I/D locus and Gallele of A2350G locus were risk alleles of developing hypertension for longterm OC users.