Effect of ciprofloxacin on immunotoxicity and muscle quality in rats

Objective To study effect of ciprofloxac in on immunotoxicity and muscle quality in rats.Methods All rats in high,middle,low dose group(44,11,5.5 mg/kg)were admin istered with intrape ritoneal injection of cipro floxac in once a day,for 7 days continuously.The thymus and spleen coefficients were calculated and morphologic change of spleniclymphocyte was observed.The changes of muscle protein content and pH values were observed.Results Thymus and spleen coefficients(mg/g)in high and low dosage group were 9.1±2.3,6.3±1.1,respectively,and those of in the controll were 6.5±1.6,3.4±0.5.The contents of muscle prote in(g/100g)in high,medium,and low dose groups were 24.68±0.55,22.48±0.54,21.22±1.25,respectively,lower than that of the control(31.83±2.36,P<0.05).Paramorphia of lymphocyte in high dose ciprofloxac in treated group was observed.Conclusion Cipro floxacin has mimunotoxicity and could reduce muscle protein significantly in rats.