Association of gene polymorphism of cholesteryl ester transfer protein with type 2 diabetes

Objective To study the association of TaqⅠ gene polymorphism with type 2 diabetes and lipodogramme in Uygur people.Methods On basis of case control design,lipodo gramme of Uygur people was determined by automatic biochemical analyzer technology and the polymorphism of cholesteryle stertransfer prote in(CETP)was analyzed by PCRR FLP in 53 type 2 diabetes mellitus(T-DM)patients,53 patients with impaired glucose to lerance(IGT)and 106 normal control of Uygur nationality.Results The fasting plasma glucose(FPG)in normal group was 5.14±0.24 mmol/L,10.79±3.34 mmol/L in T-DM group,and 5.97±0.41mmol/L in IGT group(F=205.87,P=0.000),respectively.CETP genotype distribution was significant different between the three groups(P=0.028).The frequency of H+H-geno type for T-DM was significantly higher than that of others(69.8%,45.3%,41.5% for TDM,IG T,and normal group,respectively).The values of FPG was 6.04±1.72 mmol/L for subjects with H-H-genotype,6.03±1.63 mmol/L with H+H+,and 7.48±3.60 mmol/L with H+H,respectively,with significan difference between the groups(P=0.001).The results of logistic regression showed that the dependent risk factors of T-DM were total glucose(P=0.000),CETP genotype(P=0.007),waist circum ference(P=0.048).The subjects with H+H- had a 4042 folds(95% CI=1.243-13.149,P=0.020)risk of T-DM compared with subjects with H+ H- genotype.Conclusion CET Pgene TaqⅠ polymorphism is closely related to the risk of T-DM and the H+H genotype may serve as a genetic risk factor of T-DM among Uygur people.