Endotoxin-induced oxidation damage in lung, liver and heart in mice

Objective To explore the oxidative damages caused by endotoxin(lipopolysaccharide,LPS)in lung,liver and heart in mice.Methods Twenty-four pure blood ICR mice were randomly divided into 4 groups.The treatment groups were injected intraperitoneally with LPS(5,10,15m g/kg)and the control group with normal saline.Then levels of glutathione(GSH) and lipid peroxidation(LPO)in lung,liver and heart of the mice were measured.Results LPS decreased the levels of GSH,but increased the levels of LPO in the lung,liver and heart and the oxidation dam ages of the organs increased with the increase of LPS dose.T-test showed that there were significant differences between LPS treatment groups(10m g/kg,15m g/kg)and the control group(P<0.05).The levels of oxidation damage caused by endotox in were different in different organs,and the oxidation dam age of liver,lung of treated groups were more serious.Conclusion Endo toxin can cause oxidation damage of lung,liver and heart in mice,and there is a positive correlation between the degree of damage and endotox in dose.