Association of 1858C/T gene polymorphisms of protein tyrosine phosphatase-22 with rheumatoid arthitis and systemic lupus erythematosus

Objective To probe the association of 1858C/T genepolym orphisms of protein tyrosine phospha tase-22(PTPN 22)with rheuma toid a rthitis(RA)and systemic lupusery them a tosus(SLE)in Han population in Guizhou province.Methods The 1858C/T gene polym orphism was analyzed with polyme rase cha in reaction restriction fragment lengh polymorphism(PCR-RFLP)in 110 patients with RA,98 patients with SLE and 120 healthy controls.Results The genotype of PTPN 22 1858C/T in RA,SLE and healthy controls were CC type,and the +1858C alle led is tribution was 100%.PTPN 22 1858C/T polymorphism was not found in RA patients,SLE patients and the controls.Conclusion The 1858C/T genepolymorphism of PTPN 22 was not associated with RA and SLE in Han population in Guizhou province.